Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function

Integrins are transmembrane receptors composed of α and β subunits. Although most integrins contain β1, canonical activation mechanisms are based on studies of the platelet integrin, αIIbβ3. Its inactive conformation is characterized by the association of the αIIb transmembrane and cytosolic domain...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Lu, Zhenwei, Mathew, Sijo, Chen, Jiang, Hadziselimovic, Arina, Palamuttam, Riya, Hudson, Billy G, Fässler, Reinhard, Pozzi, Ambra, Sanders, Charles R, Zent, Roy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207772/
https://ncbi.nlm.nih.gov/pubmed/27929375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18633
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