β1 Integrin NPXY Motifs Regulate Kidney Collecting-Duct Development and Maintenance by Induced-Fit Interactions with Cytosolic Proteins

Loss of β1 integrin expression inhibits renal collecting-system development. Two highly conserved NPXY motifs in the distal β1 tail regulate integrin function by associating with phosphtyrosine binding (PTB) proteins, such as talin and kindlin. Here, we define the roles of these two tyrosines in col...

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Detalhes bibliográficos
Main Authors: Mathew, Sijo, Lu, Zhenwei, Palamuttam, Riya J., Mernaugh, Glenda, Hadziselimovic, Arina, Chen, Jiang, Bulus, Nada, Gewin, Leslie S., Voehler, Markus, Meves, Alexander, Ballestrem, Christoph, Fässler, Reinhard, Pozzi, Ambra, Sanders, Charles R., Zent, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457338/
https://ncbi.nlm.nih.gov/pubmed/22869523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00568-12
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