Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit

Prostaglandin endoperoxide H synthase-2 (PGHS-2), also called cyclooxygenase-2 (COX-2), converts arachidonic acid to PGH(2). PGHS-2 is a conformational heterodimer composed of allosteric (E(allo)) and catalytic (E(cat)) subunits. Fatty acids (FAs) bind to Arg-120 of E(allo) increasing to different d...

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Vydáno v:J Biol Chem
Hlavní autoři: Dong, Liang, Yuan, Chong, Orlando, Benjamin J., Malkowski, Michael G., Smith, William L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207261/
https://ncbi.nlm.nih.gov/pubmed/27756840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757310
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