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Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit
Prostaglandin endoperoxide H synthase-2 (PGHS-2), also called cyclooxygenase-2 (COX-2), converts arachidonic acid to PGH(2). PGHS-2 is a conformational heterodimer composed of allosteric (E(allo)) and catalytic (E(cat)) subunits. Fatty acids (FAs) bind to Arg-120 of E(allo) increasing to different d...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5207261/ https://ncbi.nlm.nih.gov/pubmed/27756840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757310 |
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