Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes

Hyperinsulinemia, which is associated with aging and metabolic disease, may lead to defective protein homeostasis (proteostasis) due to hyperactivation of insulin-sensitive pathways such as protein synthesis. We investigated the effect of chronic hyperinsulinemia on proteostasis by generating a time...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Minard, Annabel Y., Wong, Martin K. L., Chaudhuri, Rima, Tan, Shi-Xiong, Humphrey, Sean J., Parker, Benjamin L., Yang, Jean Y., Laybutt, D. Ross, Cooney, Gregory J., Coster, Adelle C. F., Stöckli, Jacqueline, James, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207260/
https://ncbi.nlm.nih.gov/pubmed/27738101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.741140
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