The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex

The natural cytotoxicity receptor (NCR) NKp30 (CD337) is a key player for NK cell immunosurveillance of infections and cancer. The molecular details of ligand recognition and its connection to CD3ζ signaling remain unsolved. Here, we show that the stalk domain ((129)KEHPQLGAGTVLLLR(143)) of NKp30 is...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Memmer, Stefanie, Weil, Sandra, Beyer, Steffen, Zöller, Tobias, Peters, Eike, Hartmann, Jessica, Steinle, Alexander, Koch, Joachim
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207244/
https://ncbi.nlm.nih.gov/pubmed/27754869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.742981
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