The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex

The natural cytotoxicity receptor (NCR) NKp30 (CD337) is a key player for NK cell immunosurveillance of infections and cancer. The molecular details of ligand recognition and its connection to CD3ζ signaling remain unsolved. Here, we show that the stalk domain ((129)KEHPQLGAGTVLLLR(143)) of NKp30 is...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Memmer, Stefanie, Weil, Sandra, Beyer, Steffen, Zöller, Tobias, Peters, Eike, Hartmann, Jessica, Steinle, Alexander, Koch, Joachim
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207244/
https://ncbi.nlm.nih.gov/pubmed/27754869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.742981
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