The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex

The natural cytotoxicity receptor (NCR) NKp30 (CD337) is a key player for NK cell immunosurveillance of infections and cancer. The molecular details of ligand recognition and its connection to CD3ζ signaling remain unsolved. Here, we show that the stalk domain ((129)KEHPQLGAGTVLLLR(143)) of NKp30 is...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Memmer, Stefanie, Weil, Sandra, Beyer, Steffen, Zöller, Tobias, Peters, Eike, Hartmann, Jessica, Steinle, Alexander, Koch, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207244/
https://ncbi.nlm.nih.gov/pubmed/27754869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.742981
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