A Soluble Fragment of the Tumor Antigen BCL2-associated Athanogene 6 (BAG-6) Is Essential and Sufficient for Inhibition of NKp30 Receptor-dependent Cytotoxicity of Natural Killer Cells

Immunosurveillance of tumor cells depends on NKp30, a major activating receptor of human natural killer (NK) cells. The human BCL2-associated athanogene 6 (BAG-6, also known as BAT3; 1126 amino acids) is a cellular ligand of NKp30. To date, little is known about the molecular details of this recepto...

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Detalhes bibliográficos
Main Authors: Binici, Janina, Hartmann, Jessica, Herrmann, Julia, Schreiber, Christine, Beyer, Steffen, Güler, Günnur, Vogel, Vitali, Tumulka, Franz, Abele, Rupert, Mäntele, Werner, Koch, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843045/
https://ncbi.nlm.nih.gov/pubmed/24133212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.483602
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