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The Orai1 Store-operated Calcium Channel Functions as a Hexamer

Orai channels mediate store-operated Ca(2+) signals crucial in regulating transcription in many cell types, and implicated in numerous immunological and inflammatory disorders. Despite their central importance, controversy surrounds the basic subunit structure of Orai channels, with several biochemi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Cai, Xiangyu, Zhou, Yandong, Nwokonko, Robert M., Loktionova, Natalia A., Wang, Xianming, Xin, Ping, Trebak, Mohamed, Wang, Youjun, Gill, Donald L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207053/
https://ncbi.nlm.nih.gov/pubmed/27780862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.758813
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