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Probing conformational dynamics of an enzymatic active site by an in situ single fluorogenic probe under piconewton force manipulation
Unraveling the conformational details of an enzyme during the essential steps of a catalytic reaction (i.e., enzyme–substrate interaction, enzyme–substrate active complex formation, nascent product formation, and product release) is challenging due to the transient nature of intermediate conformatio...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206548/ https://ncbi.nlm.nih.gov/pubmed/27940917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613404114 |
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