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Conservation of coevolving protein interfaces bridges prokaryote–eukaryote homologies in the twilight zone

Protein–protein interactions are fundamental for the proper functioning of the cell. As a result, protein interaction surfaces are subject to strong evolutionary constraints. Recent developments have shown that residue coevolution provides accurate predictions of heterodimeric protein interfaces fro...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Rodriguez-Rivas, Juan, Marsili, Simone, Juan, David, Valencia, Alfonso
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206536/
https://ncbi.nlm.nih.gov/pubmed/27965389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611861114
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