The cell cycle restricts activation-induced cytidine deaminase activity to early G1

Activation-induced cytidine deaminase (AID) converts cytosine into uracil to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of antibody genes. In addition, this enzyme produces DNA lesions at off-target sites that lead to mutations and chromosome translocations. However, A...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Wang, Qiao, Kieffer-Kwon, Kyong-Rim, Oliveira, Thiago Y., Mayer, Christian T., Yao, Kaihui, Pai, Joy, Cao, Zhen, Dose, Marei, Casellas, Rafael, Jankovic, Mila, Nussenzweig, Michel C., Robbiani, Davide F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206505/
https://ncbi.nlm.nih.gov/pubmed/27998928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161649
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