FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

The forkhead box O3a (FOXO3a) transcription factor has been shown to regulate glucose metabolism, muscle atrophy, and cell death in postmitotic cells. Its role in regulation of mitochondrial and myocardial function is not well studied. Based on previous work, we hypothesized that FOXO3a, through BCL...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Chaanine, Antoine H., Kohlbrenner, Erik, Gamb, Scott I., Guenzel, Adam J., Klaus, Katherine, Fayyaz, Ahmed U., Nair, K. Sreekumaran, Hajjar, Roger J., Redfield, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206339/
https://ncbi.nlm.nih.gov/pubmed/27694219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00549.2016
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