JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure

Bcl-2 E1B 19-KDa interacting protein 3 (BNIP3) is a mitochondrial death and mitophagy marker, which is involved in inducing cardiac remodeling post myocardial infarction. In this study, we show that BNIP3 expression increases in stressed cardiomyocytes in vitro and in response to pressure overload i...

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Detalhes bibliográficos
Main Authors: Chaanine, A H, Jeong, D, Liang, L, Chemaly, E R, Fish, K, Gordon, R E, Hajjar, R J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288347/
https://ncbi.nlm.nih.gov/pubmed/22297293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.5
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