FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

The forkhead box O3a (FOXO3a) transcription factor has been shown to regulate glucose metabolism, muscle atrophy, and cell death in postmitotic cells. Its role in regulation of mitochondrial and myocardial function is not well studied. Based on previous work, we hypothesized that FOXO3a, through BCL...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Chaanine, Antoine H., Kohlbrenner, Erik, Gamb, Scott I., Guenzel, Adam J., Klaus, Katherine, Fayyaz, Ahmed U., Nair, K. Sreekumaran, Hajjar, Roger J., Redfield, Margaret M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
Schlagworte:
Signaling and Stress Response
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206339/
https://ncbi.nlm.nih.gov/pubmed/27694219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00549.2016
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