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Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.

Investigations of the actions and interactions of the immunophilin ligands FK506, cyclosporin A (CsA), rapamycin, and 506BD suggest that complexes of FK506 with an FK506-binding protein or of CsA with a cyclophilin (CsA-binding protein) inhibit the T-cell receptor-mediated signal transduction that r...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hultsch, T, Albers, M W, Schreiber, S L, Hohman, R J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52056/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1712484/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.14.6229
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