Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.
Investigations of the actions and interactions of the immunophilin ligands FK506, cyclosporin A (CsA), rapamycin, and 506BD suggest that complexes of FK506 with an FK506-binding protein or of CsA with a cyclophilin (CsA-binding protein) inhibit the T-cell receptor-mediated signal transduction that r...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1991
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1712484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.14.6229 |
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