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Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.

Investigations of the actions and interactions of the immunophilin ligands FK506, cyclosporin A (CsA), rapamycin, and 506BD suggest that complexes of FK506 with an FK506-binding protein or of CsA with a cyclophilin (CsA-binding protein) inhibit the T-cell receptor-mediated signal transduction that r...

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Библиографические подробности
Главные авторы: Hultsch, T, Albers, M W, Schreiber, S L, Hohman, R J
Формат: Artigo
Язык:Inglês
Опубликовано: 1991
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC52056/
https://ncbi.nlm.nih.gov/pubmed/1712484
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