Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.

Investigations of the actions and interactions of the immunophilin ligands FK506, cyclosporin A (CsA), rapamycin, and 506BD suggest that complexes of FK506 with an FK506-binding protein or of CsA with a cyclophilin (CsA-binding protein) inhibit the T-cell receptor-mediated signal transduction that r...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hultsch, T, Albers, M W, Schreiber, S L, Hohman, R J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1712484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.14.6229
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