NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

Metabolic regulation has been implicated in the pathogenesis of inflammatory diseases. NADPH oxidase 4 (NOX4), a source of cellular superoxide anion, has multiple biological functions that may be of importance in inflammation, and in the pathogenesis of human metabolic diseases, including diabetes....

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Veröffentlicht in:Nat Med
Hauptverfasser: Moon, Jong-Seok, Nakahira, Kiichi, Chung, Kuei-Pin, DeNicola, Gina M., Koo, Michael Jakun, Pabón, Maria A., Rooney, Kristen T., Yoon, Joo-Heon, Ryter, Stefan W., Stout-Delgado, Heather, Choi, Augustine M. K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204248/
https://ncbi.nlm.nih.gov/pubmed/27455510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4153
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