Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia

The survival and proliferation of CLL cells depends on microenvironmental contacts in lymphoid organs. CD38 is a cell surface receptor that plays an important role in survival and proliferation signaling in CLL. In this study we demonstrate SYK's direct involvement in the CD38 signaling pathway...

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Udgivet i:PLoS One
Main Authors: Benkisser-Petersen, Marco, Buchner, Maike, Dörffel, Arlette, Dühren-von-Minden, Marcus, Claus, Rainer, Kläsener, Kathrin, Leberecht, Kerstin, Burger, Meike, Dierks, Christine, Jumaa, Hassan, Malavasi, Fabio, Reth, Michael, Veelken, Hendrik, Duyster, Justus, Zirlik, Katja
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201248/
https://ncbi.nlm.nih.gov/pubmed/28036404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169159
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