Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia

The survival and proliferation of CLL cells depends on microenvironmental contacts in lymphoid organs. CD38 is a cell surface receptor that plays an important role in survival and proliferation signaling in CLL. In this study we demonstrate SYK's direct involvement in the CD38 signaling pathway...

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Publicat a:PLoS One
Autors principals: Benkisser-Petersen, Marco, Buchner, Maike, Dörffel, Arlette, Dühren-von-Minden, Marcus, Claus, Rainer, Kläsener, Kathrin, Leberecht, Kerstin, Burger, Meike, Dierks, Christine, Jumaa, Hassan, Malavasi, Fabio, Reth, Michael, Veelken, Hendrik, Duyster, Justus, Zirlik, Katja
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201248/
https://ncbi.nlm.nih.gov/pubmed/28036404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169159
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