Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia

Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) is known to play an important role in the pathogenesis of chronic lymphocytic leukemia (CLL). Several NF-κB inhibitors were shown to successfully induce apoptosis of CLL cells in vitro. Since the microenvironment is known to be cruci...

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Publicado no:Haematologica
Main Authors: Simon-Gabriel, Carl Philipp, Foerster, Katharina, Saleem, Shifa, Bleckmann, Dorothee, Benkisser-Petersen, Marco, Thornton, Nicolas, Umezawa, Kazuo, Decker, Sarah, Burger, Meike, Veelken, Hendrik, Claus, Rainer, Dierks, Christine, Duyster, Justus, Zirlik, Katja
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777201/
https://ncbi.nlm.nih.gov/pubmed/29122993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.165381
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