Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents – A Potential Therapy for Cancer

Poly (ADP-ribose) polymerase inhibitors (PARPis) are clinically effective predominantly for BRCA-mutant tumors. We introduce a mechanism-based strategy to enhance PARPi efficacy based on DNA damage-related binding between DNA methyltransferases (DNMTs) and PARP1. In AML and breast cancer cells, DNMT...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Muvarak, Nidal E., Chowdhury, Khadiza, Xia, Limin, Robert, Carine, Choi, Eun Yong, Cai, Yi, Bellani, Marina, Zou, Ying, Singh, Zeba N., Duong, Vu H., Rutherford, Tyler, Nagaria, Pratik, Bentzen, Søren M., Seidman, Michael M., Baer, Maria R., Lapidus, Rena G., Baylin, Stephen B., Rassool, Feyruz V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201166/
https://ncbi.nlm.nih.gov/pubmed/27728808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.09.002
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