Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents – A Potential Therapy for Cancer

Poly (ADP-ribose) polymerase inhibitors (PARPis) are clinically effective predominantly for BRCA-mutant tumors. We introduce a mechanism-based strategy to enhance PARPi efficacy based on DNA damage-related binding between DNA methyltransferases (DNMTs) and PARP1. In AML and breast cancer cells, DNMT...

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Udgivet i:Cancer Cell
Main Authors: Muvarak, Nidal E., Chowdhury, Khadiza, Xia, Limin, Robert, Carine, Choi, Eun Yong, Cai, Yi, Bellani, Marina, Zou, Ying, Singh, Zeba N., Duong, Vu H., Rutherford, Tyler, Nagaria, Pratik, Bentzen, Søren M., Seidman, Michael M., Baer, Maria R., Lapidus, Rena G., Baylin, Stephen B., Rassool, Feyruz V.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201166/
https://ncbi.nlm.nih.gov/pubmed/27728808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.09.002
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