Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve mouse embryonic stem cell (ESC) WNT and MEK/ERK signal inhibition (2i) culture. We show that a br...

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Enregistré dans:
Détails bibliographiques
Publié dans:Development
Auteurs principaux: Zimmerlin, Ludovic, Park, Tea Soon, Huo, Jeffrey S., Verma, Karan, Pather, Sarshan R., Talbot, C. Conover, Agarwal, Jasmin, Steppan, Diana, Zhang, Yang W., Considine, Michael, Guo, Hong, Zhong, Xiufeng, Gutierrez, Christian, Cope, Leslie, Canto-Soler, M. Valeria, Friedman, Alan D., Baylin, Stephen B., Zambidis, Elias T.
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists Ltd 2016
Sujets:
Stem Cells and Regeneration
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201042/
https://ncbi.nlm.nih.gov/pubmed/27660325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.138982
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