Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve mouse embryonic stem cell (ESC) WNT and MEK/ERK signal inhibition (2i) culture. We show that a br...

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Vydáno v:Development
Hlavní autoři: Zimmerlin, Ludovic, Park, Tea Soon, Huo, Jeffrey S., Verma, Karan, Pather, Sarshan R., Talbot, C. Conover, Agarwal, Jasmin, Steppan, Diana, Zhang, Yang W., Considine, Michael, Guo, Hong, Zhong, Xiufeng, Gutierrez, Christian, Cope, Leslie, Canto-Soler, M. Valeria, Friedman, Alan D., Baylin, Stephen B., Zambidis, Elias T.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2016
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201042/
https://ncbi.nlm.nih.gov/pubmed/27660325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.138982
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