Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve mouse embryonic stem cell (ESC) WNT and MEK/ERK signal inhibition (2i) culture. We show that a br...

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Detaylı Bibliyografya
Yayımlandı:Development
Asıl Yazarlar: Zimmerlin, Ludovic, Park, Tea Soon, Huo, Jeffrey S., Verma, Karan, Pather, Sarshan R., Talbot, C. Conover, Agarwal, Jasmin, Steppan, Diana, Zhang, Yang W., Considine, Michael, Guo, Hong, Zhong, Xiufeng, Gutierrez, Christian, Cope, Leslie, Canto-Soler, M. Valeria, Friedman, Alan D., Baylin, Stephen B., Zambidis, Elias T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2016
Konular:
Stem Cells and Regeneration
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201042/
https://ncbi.nlm.nih.gov/pubmed/27660325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.138982
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