Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve mouse embryonic stem cell (ESC) WNT and MEK/ERK signal inhibition (2i) culture. We show that a br...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Development
Main Authors: Zimmerlin, Ludovic, Park, Tea Soon, Huo, Jeffrey S., Verma, Karan, Pather, Sarshan R., Talbot, C. Conover, Agarwal, Jasmin, Steppan, Diana, Zhang, Yang W., Considine, Michael, Guo, Hong, Zhong, Xiufeng, Gutierrez, Christian, Cope, Leslie, Canto-Soler, M. Valeria, Friedman, Alan D., Baylin, Stephen B., Zambidis, Elias T.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2016
Fag:
Stem Cells and Regeneration
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201042/
https://ncbi.nlm.nih.gov/pubmed/27660325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.138982
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker