Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

The derivation and maintenance of human pluripotent stem cells (hPSCs) in stable naïve pluripotent states has a wide impact in human developmental biology. However, hPSCs are unstable in classical naïve mouse embryonic stem cell (ESC) WNT and MEK/ERK signal inhibition (2i) culture. We show that a br...

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Detalles Bibliográficos
Publicado en:Development
Main Authors: Zimmerlin, Ludovic, Park, Tea Soon, Huo, Jeffrey S., Verma, Karan, Pather, Sarshan R., Talbot, C. Conover, Agarwal, Jasmin, Steppan, Diana, Zhang, Yang W., Considine, Michael, Guo, Hong, Zhong, Xiufeng, Gutierrez, Christian, Cope, Leslie, Canto-Soler, M. Valeria, Friedman, Alan D., Baylin, Stephen B., Zambidis, Elias T.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2016
Assuntos:
Stem Cells and Regeneration
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201042/
https://ncbi.nlm.nih.gov/pubmed/27660325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.138982
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