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Six3 dosage mediates the pathogenesis of holoprosencephaly

Holoprosencephaly (HPE) is defined as the incomplete separation of the two cerebral hemispheres. The pathology of HPE is variable and, based on the severity of the defect, HPE is divided into alobar, semilobar, and lobar. Using a novel hypomorphic Six3 allele, we demonstrate in mice that variability...

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Библиографические подробности
Опубликовано в: :Development
Главные авторы: Geng, Xin, Acosta, Sandra, Lagutin, Oleg, Gil, Hyea Jin, Oliver, Guillermo
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201039/
https://ncbi.nlm.nih.gov/pubmed/27770010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.132142
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