An eye organoid approach identifies Six3 suppression of R-spondin 2 as a critical step in mouse neuroretina differentiation

Recent advances in self-organizing, 3-dimensional tissue cultures of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provided an in vitro model that recapitulates many aspects of the in vivo developmental steps. Using Rax-GFP expressing ESCs, newly generated Six3(−/−) iPSCs an...

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Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Takata, Nozomu, Abbey, Deepti, Fiore, Luciano, Acosta, Sandra, Feng, Ruopeng, Gil, Hyea Jin, Lavado, Alfonso, Geng, Xin, Interiano, Ashley, Neale, Geoffrey, Eiraku, Mototsugu, Sasai, Yoshiki, Oliver, Guillermo
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728169/
https://ncbi.nlm.nih.gov/pubmed/29117559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.041
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