An eye organoid approach identifies Six3 suppression of R-spondin 2 as a critical step in mouse neuroretina differentiation

Recent advances in self-organizing, 3-dimensional tissue cultures of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provided an in vitro model that recapitulates many aspects of the in vivo developmental steps. Using Rax-GFP expressing ESCs, newly generated Six3(−/−) iPSCs an...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Takata, Nozomu, Abbey, Deepti, Fiore, Luciano, Acosta, Sandra, Feng, Ruopeng, Gil, Hyea Jin, Lavado, Alfonso, Geng, Xin, Interiano, Ashley, Neale, Geoffrey, Eiraku, Mototsugu, Sasai, Yoshiki, Oliver, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728169/
https://ncbi.nlm.nih.gov/pubmed/29117559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.041
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