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Six3 dosage mediates the pathogenesis of holoprosencephaly
Holoprosencephaly (HPE) is defined as the incomplete separation of the two cerebral hemispheres. The pathology of HPE is variable and, based on the severity of the defect, HPE is divided into alobar, semilobar, and lobar. Using a novel hypomorphic Six3 allele, we demonstrate in mice that variability...
Tallennettuna:
| Julkaisussa: | Development |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Company of Biologists Ltd
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5201039/ https://ncbi.nlm.nih.gov/pubmed/27770010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.132142 |
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