Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly

Holoprosencephaly (HPE), the most common forebrain malformation, is characterized by an incomplete separation of the cerebral hemispheres. Mutations in the homeobox gene SIX3 account for 1.3% of all cases of human HPE. Using zebrafish-based assays, we have now determined that HPE-associated Six3 mut...

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Detalhes bibliográficos
Main Authors: Geng, Xin, Speirs, Christina, Lagutin, Oleg, Inbal, Adi, Liu, Wei, Solnica-Krezel, Lilianna, Jeong, Yongsu, Epstein, Douglas, Oliver, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597207/
https://ncbi.nlm.nih.gov/pubmed/18694563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.07.003
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