Regulation of a remote Sonic hedgehog forebrain enhancer by the Six3 homeoprotein

The secreted morphogen, Sonic hedgehog (Shh) is a significant determinant of brain size and craniofacial morphology1–4. In humans, SHH haploinsufficiency results in holoprosencephaly (HPE)5, a defect in anterior midline formation. Despite the importance of maintaining SHH transcript levels above a c...

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Detalhes bibliográficos
Main Authors: Jeong, Yongsu, Leskow, Federico Coluccio, El-Jaick, Kenia, Roessler, Erich, Muenke, Maximilian, Yocum, Anastasia, Dubourg, Christele, Li, Xue, Geng, Xin, Oliver, Guillermo, Epstein, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648611/
https://ncbi.nlm.nih.gov/pubmed/18836447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.230
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