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Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor-suppressor gene syndrome caused by inactivating mutations in either TSC1 or TSC2, and the TSC protein complex is an essential regulator of mTOR complex 1 (mTORC1). Patients with TSC develop hypomelanotic macules (white spots), but the m...
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| Izdano u: | J Clin Invest |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5199706/ https://ncbi.nlm.nih.gov/pubmed/27918305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84262 |
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