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Tuberous sclerosis complex–associated CNS abnormalities depend on hyperactivation of mTORC1 and Akt

Tuberous sclerosis complex (TSC) is a dominantly inherited disease caused by hyperactivation of the mTORC1 pathway and characterized by the development of hamartomas and benign tumors, including in the brain. Among the neurological manifestations associated with TSC, the tumor progression of static...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zordan, Paola, Cominelli, Manuela, Cascino, Federica, Tratta, Elisa, Poliani, Pietro L., Galli, Rossella
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873854/
https://ncbi.nlm.nih.gov/pubmed/29389670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96342
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