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Tuberous sclerosis complex–associated CNS abnormalities depend on hyperactivation of mTORC1 and Akt

Tuberous sclerosis complex (TSC) is a dominantly inherited disease caused by hyperactivation of the mTORC1 pathway and characterized by the development of hamartomas and benign tumors, including in the brain. Among the neurological manifestations associated with TSC, the tumor progression of static...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Zordan, Paola, Cominelli, Manuela, Cascino, Federica, Tratta, Elisa, Poliani, Pietro L., Galli, Rossella
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873854/
https://ncbi.nlm.nih.gov/pubmed/29389670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96342
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