Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development

Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), caused by loss-of-function mutations in either the TSC1 or TSC2 gene, leads to the development of tuberous sclerosis complex (TSC), a benign tumor syndrome with multiple affected organs. mTORC1-mediated inhibition of AKT constrains...

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Udgivet i:Oncotarget
Main Authors: Wang, Li, Ni, Zhaofei, Liu, Yujie, Ji, Shuang, Jin, Fuquan, Jiang, Keguo, Ma, Junfang, Ren, Cuiping, Zhang, Hongbing, Hu, Zhongdong, Zha, Xiaojun
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589626/
https://ncbi.nlm.nih.gov/pubmed/28903387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18963
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