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Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype
Hutchinson-Gilford syndrome (HGPS, OMIM 176670, a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene. Lamins help maintain the shape and stability of the nuclear envelope in addition to reg...
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| Publicado en: | PLoS One |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5199099/ https://ncbi.nlm.nih.gov/pubmed/28033363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168988 |
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