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Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype

Hutchinson-Gilford syndrome (HGPS, OMIM 176670, a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene. Lamins help maintain the shape and stability of the nuclear envelope in addition to reg...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Gabriel, Diana, Gordon, Leslie B., Djabali, Karima
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199099/
https://ncbi.nlm.nih.gov/pubmed/28033363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168988
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