Inhibition of RAS function through targeting an allosteric regulatory site

RAS GTPases are important mediators of oncogenesis in humans. However, pharmacological inhibition of RAS has proved challenging. Here, we describe a functionally critical region of RAS located outside the effector lobe that can be targeted for inhibition. We developed a synthetic binding protein (mo...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Spencer-Smith, Russell, Koide, Akiko, Zhou, Yong, Eguchi, Raphael R., Sha, Fern, Gajwani, Priyanka, Santana, Dianicha, Gupta, Ankit, Jacobs, Miranda, Herrero-Garcia, Erika, Cobbert, Jacqueline, Lavoie, Hugo, Smith, Matthew, Rajakulendran, Thanashan, Dowdell, Evan, Okur, Mustafa Nazir, Dementieva, Irina, Sicheri, Frank, Therrien, Marc, Hancock, John F., Ikura, Mitsuhiko, Koide, Shohei, O’Bryan, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193369/
https://ncbi.nlm.nih.gov/pubmed/27820802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2231
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