EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer

EYA1 is known to be overexpressed in human breast cancer, in which the Myc protein is also accumulated in association with decreased phospho-T58 (pT58) levels. We have recently reported that EYA1 functions as a unique protein phosphatase to dephosphorylate Myc at pT58 to regulate Myc levels. However...

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Bibliografski detalji
Izdano u:Mol Cell Biol
Glavni autori: Li, Jun, Rodriguez, Yoel, Cheng, Chunming, Zeng, Lei, Wong, Elaine Y. M., Xu, Chelsea Y., Zhou, Ming-Ming, Xu, Pin-Xian
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192086/
https://ncbi.nlm.nih.gov/pubmed/27795300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00499-16
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