EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer

EYA1 is known to be overexpressed in human breast cancer, in which the Myc protein is also accumulated in association with decreased phospho-T58 (pT58) levels. We have recently reported that EYA1 functions as a unique protein phosphatase to dephosphorylate Myc at pT58 to regulate Myc levels. However...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Mol Cell Biol
المؤلفون الرئيسيون: Li, Jun, Rodriguez, Yoel, Cheng, Chunming, Zeng, Lei, Wong, Elaine Y. M., Xu, Chelsea Y., Zhou, Ming-Ming, Xu, Pin-Xian
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2016
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192086/
https://ncbi.nlm.nih.gov/pubmed/27795300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00499-16
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