EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer

EYA1 is known to be overexpressed in human breast cancer, in which the Myc protein is also accumulated in association with decreased phospho-T58 (pT58) levels. We have recently reported that EYA1 functions as a unique protein phosphatase to dephosphorylate Myc at pT58 to regulate Myc levels. However...

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Pubblicato in:Mol Cell Biol
Autori principali: Li, Jun, Rodriguez, Yoel, Cheng, Chunming, Zeng, Lei, Wong, Elaine Y. M., Xu, Chelsea Y., Zhou, Ming-Ming, Xu, Pin-Xian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192086/
https://ncbi.nlm.nih.gov/pubmed/27795300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00499-16
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