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Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration

Mechanisms of brain and retinal iron homeostasis have become subjects of increased interest after the discovery of elevated iron levels in brains of patients with Alzheimer's disease and retinas of patients with age-related macular degeneration. To determine whether the ferroxidase ceruloplasmi...

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Bibliografiske detaljer
Main Authors: Hahn, Paul, Qian, Ying, Dentchev, Tzvete, Chen, Lin, Beard, John, Harris, Zena Leah, Dunaief, Joshua L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC518844/
https://ncbi.nlm.nih.gov/pubmed/15365174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405146101
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