Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin

BACKGROUND & AIMS: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe(2+) from the iron exporter ferroportin 1 for delivery to the circulating Fe(3+) carrier transferrin. Hephaestin (HEPH), the...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Fuqua, Brie K., Lu, Yan, Frazer, David M., Darshan, Deepak, Wilkins, Sarah J., Dunn, Linda, Loguinov, Alex V., Kogan, Scott C., Matak, Pavle, Chen, Huijun, Dunaief, Joshua L., Vulpe, Chris D., Anderson, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120670/
https://ncbi.nlm.nih.gov/pubmed/30182051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.06.006
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