Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin

BACKGROUND & AIMS: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe(2+) from the iron exporter ferroportin 1 for delivery to the circulating Fe(3+) carrier transferrin. Hephaestin (HEPH), the...

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Bibliografski detalji
Izdano u:Cell Mol Gastroenterol Hepatol
Glavni autori: Fuqua, Brie K., Lu, Yan, Frazer, David M., Darshan, Deepak, Wilkins, Sarah J., Dunn, Linda, Loguinov, Alex V., Kogan, Scott C., Matak, Pavle, Chen, Huijun, Dunaief, Joshua L., Vulpe, Chris D., Anderson, Gregory J.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120670/
https://ncbi.nlm.nih.gov/pubmed/30182051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.06.006
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