The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration

PURPOSE. Iron-induced oxidative stress may exacerbate age-related macular degeneration (AMD). Ceruloplasmin/Hephaestin double-knockout (DKO) mice with age-dependent retinal iron accumulation and some features of AMD were used to test retinal protection by the oral iron chelator deferiprone (DFP). ME...

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Main Authors: Hadziahmetovic, Majda, Song, Ying, Wolkow, Natalie, Iacovelli, Jared, Grieco, Steven, Lee, Jennifer, Lyubarsky, Arkady, Pratico, Domenico, Connelly, John, Spino, Michael, Harris, Z. Leah, Dunaief, Joshua L.
Format: Artigo
Language:Inglês
Published: Association for Research in Vision and Ophthalmology, Inc. 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183363/
https://ncbi.nlm.nih.gov/pubmed/21051716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6207
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