The Oral Iron Chelator Deferiprone Protects Against Systemic Iron Overload–Induced Retinal Degeneration in Hepcidin Knockout Mice

PURPOSE. To investigate the retinal-protective effects of the oral iron chelator deferiprone (DFP) in mice lacking the iron regulatory hormone hepcidin (Hepc). These Hepc knockout (KO) mice have age-dependent systemic and retinal iron accumulation leading to retinal degeneration. METHODS. Hepc KO mi...

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Bibliographische Detailangaben
Hauptverfasser: Song, Delu, Zhao, Liangliang, Li, Yafeng, Hadziahmetovic, Majda, Song, Ying, Connelly, John, Spino, Michael, Dunaief, Joshua L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106252/
https://ncbi.nlm.nih.gov/pubmed/24970260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14568
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