Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

Intron lariats are circular, branched RNAs (bRNAs) produced during pre-mRNA splicing. Their unusual chemical and topological properties arise from branch-point nucleotides harboring vicinal 2′,5′- and 3′,5′-phosphodiester linkages. The 2′,5′-bonds must be hydrolyzed by the RNA debranching enzyme Dbr...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Clark, Nathaniel E., Katolik, Adam, Roberts, Kenneth M., Taylor, Alexander B., Holloway, Stephen P., Schuermann, Jonathan P., Montemayor, Eric J., Stevens, Scott W., Fitzpatrick, Paul F., Damha, Masad J., Hart, P. John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187747/
https://ncbi.nlm.nih.gov/pubmed/27930312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612729114
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