Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

Intron lariats are circular, branched RNAs (bRNAs) produced during pre-mRNA splicing. Their unusual chemical and topological properties arise from branch-point nucleotides harboring vicinal 2′,5′- and 3′,5′-phosphodiester linkages. The 2′,5′-bonds must be hydrolyzed by the RNA debranching enzyme Dbr...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Clark, Nathaniel E., Katolik, Adam, Roberts, Kenneth M., Taylor, Alexander B., Holloway, Stephen P., Schuermann, Jonathan P., Montemayor, Eric J., Stevens, Scott W., Fitzpatrick, Paul F., Damha, Masad J., Hart, P. John
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187747/
https://ncbi.nlm.nih.gov/pubmed/27930312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612729114
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares