Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1

Intron lariats are circular, branched RNAs (bRNAs) produced during pre-mRNA splicing. Their unusual chemical and topological properties arise from branch-point nucleotides harboring vicinal 2′,5′- and 3′,5′-phosphodiester linkages. The 2′,5′-bonds must be hydrolyzed by the RNA debranching enzyme Dbr...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Clark, Nathaniel E., Katolik, Adam, Roberts, Kenneth M., Taylor, Alexander B., Holloway, Stephen P., Schuermann, Jonathan P., Montemayor, Eric J., Stevens, Scott W., Fitzpatrick, Paul F., Damha, Masad J., Hart, P. John
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187747/
https://ncbi.nlm.nih.gov/pubmed/27930312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612729114
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