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Design, synthesis and properties of phosphoramidate 2′,5′-linked branched RNA: Towards the rational design of inhibitors of the RNA Lariat Debranching Enzyme
Two RNA fragments linked by means of a 2′,5′ phosphodiester bridge (2′ hydroxyl of one fragment connected to the 5′ hydroxyl of the other) constitute a class of nucleic acids known as 2′-5′ branched RNAs (bRNAs,). In this report we show that bRNA analogues containing 2′-5′ phosphoramidate linkages (...
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| Publicado no: | J Org Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749351/ https://ncbi.nlm.nih.gov/pubmed/26378468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b01719 |
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