Design, synthesis and properties of phosphoramidate 2′,5′-linked branched RNA: Towards the rational design of inhibitors of the RNA Lariat Debranching Enzyme

Two RNA fragments linked by means of a 2′,5′ phosphodiester bridge (2′ hydroxyl of one fragment connected to the 5′ hydroxyl of the other) constitute a class of nucleic acids known as 2′-5′ branched RNAs (bRNAs,). In this report we show that bRNA analogues containing 2′-5′ phosphoramidate linkages (...

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Vydáno v:J Org Chem
Hlavní autoři: Tago, Nobuhiro, Katolik, Adam, Clark, Nathaniel E., Montemayor, Eric J., Seio, Kohji, Sekine, Mitsuo, Hart, P. John, Damha, Masad J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749351/
https://ncbi.nlm.nih.gov/pubmed/26378468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.5b01719
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